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This higher rate is expected when combining two appetite-suppressing compounds
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Retatrutide — TRIUMPH-1 (2023) and TRIUMPH-2 (2024) TRIUMPH-1 (Jastreboff et al., NEJM 2023): 338 non-diabetic adults with obesity, 48 weeks at escalating doses: 12 mg dose: −24.2% weight loss 8 mg dose: −22.8% 4 mg dose: −17.5% Placebo: −2.1% TRIUMPH-2 (Rosenstock et al., Lancet 2024) confirmed effects in T2D patients with concurrent NAFLD improvement (hepatic fat reduction −54% at 24 weeks, 12 mg dose)
